What Is Buprenorphine?

Buprenorphine is a partial opioid agonist primarily used to treat opioid use disorder (OUD) and severe pain. It helps in reducing opioid withdrawals and cravings caused by opioid dependence.

This medication is a very valuable tool in medication-assisted treatment (MAT) of opioid use disorder (OUD). It is also an essential element used in the effective treatment plan of OUD combined with counseling and behavioral therapy.

It also helps in reducing depression symptoms and suicidal thoughts, and when taken at analgesic doses, Buprenorphine is 20 – 50 times more potent than Morphine.

It offers several benefits to people with opioid dependency and addiction and those who are allergic to methadone and do not prefer treatment in a methadone clinic or when it’s not sufficient for them.

Buprenorphine comes in a round-shaped white tablet with its strength imprinted on one side that is available in 2 mg, 4 mg, 8 mg, and 12 mg strength.

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Why Buprenorphine Is Used

Opioid Use Disorder (OUD)

This medication helps people with opioid use disorder and alcohol addiction and reduces opioid cravings and withdrawal symptoms caused by opioid overdose. Being a synthetic opioid agonist, it is an essential part of the treatment plan for Opioid Use Disorder (OUD) that is combined with social and behavioral training and individual counseling to help with OUD and to provide a whole-person approach.

Buprenorphine treatment helps in –

• Lowering the risk of opioid abuse
• Diminishing opioid dependency and addiction
• Reducing opioid cravings and withdrawals
• Increasing safety in case of overdose

Severe Pain

This medication is also used to treat and manage severe pain and provides instant relief from pain caused by opioid withdrawal symptoms. It offers various benefits to people with opioid addiction and to those whose treatment in a methadone clinic is not preferred or sufficient and is less convenient for them.

How It Works

Buprenorphine works by binding to several opioid receptors of the brain and attaches to it more strongly than any other opioid medications. It helps to reduce feelings of pain by interrupting the way nerves signal the pain between the brain and the body.

It eliminates the effects of other opioid medications, reduces the negative effects of withdrawals, and prevents the harm associated with opioid use.

This medication starts working within 1 – 2 hours of using the medication, and it has a relatively rapid onset of action than Methadone.

What Should I Tell My Healthcare Provider Before Using Buprenorphine?

Most adults can use Buprenorphine on a doctor’s prescription, but people with certain health conditions are not recommended to use this medication even on a doctor’s prescription.

Tell your doctor before using Buprenorphine if you have –

• Hypersensitivity
• Seizures or fits
• Low blood pressure
• Severe liver disease
• Urination problems
• Breathing problems
• Severe heart disease
• History of alcohol abuse
• Stomach or bowel blockage
• Used any narcotic drug in the last 4 days.

How To Take The Dose

The dose depends on various factors such as age, health, and in-depth health assessment by a doctor. It is prescribed for short-term use because of its potential for abuse, misuse, and addiction.

Sublingual Tablets –

• The recommended dose to be used after treatment, induction, and stabilization is 4 – 24 mg taken sublingually in a day.
• The target dose of this medication is 16 mg, which is taken in a day.
• Do not exceed Buprenorphine doses to more than 24 mg strength in a day.
• You must take the doses as recommended by your doctor or a healthcare professional for safe use and effective Opioid Use Disorder (OUD) treatment.

Possible Side Effects Of Buprenorphine

Buprenorphine causes mild side effects that are not harmful, and it does not cause any serious health issues.

Some of the common and most noticeable side effects caused by Buprenorphine are given below –

• Fever
• Confusion
• Headache
• Cravings
• Irritability
• Nausea
• Vomiting
• Constipation
• Muscle aches or cramps
• Sleepiness and tiredness
• Rashes and redness on the skin

What To Prevent While Using Buprenorphine

You must remember these preventative measures while using Buprenorphine for safe and effective treatment.

• Do not drink alcohol before if you are continuing Buprenorphine to prevent severe withdrawals.
• Avoid using any benzodiazepine or any other CNS depressant medication during this treatment.
• Take a smaller dose, and monitor for any side effects if you have liver-related problems or disease.
• Doctors do not recommend Buprenorphine for pregnant and nursing mothers to prevent any harm to the baby.
• If you experience any unusual allergic reaction, stop the treatment immediately.
• If you are continuing this medication, avoid using sedatives, tranquilizers, and any illicit drugs. Otherwise, the drugs will interact, which can affect your breathing.

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Conclusion

If this medication is not used as prescribed by a doctor, it can be harmful, as it carries a risk of abuse, misuse, and dependence, but the risks are lower than those of Methadone.

Do not use Buprenorphine for a longer period of time; otherwise, you may develop dependency and get addicted to it. People who are not diagnosed with opioid use disorder (OUD) should not use this medication.

Avoid sharing this medication with older adults, and keep it out of reach of children. If your treatment has been completed, you must return the tablets to a pharmacy or a medical store to prevent any abuse, misuse, and dependence.

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